Mutational Analysis of the Coding Regiosn of the Genes Encoding nProtein Kinase B-α and -β, Phosphoinositide-Dependent Protein Kinase-1, Phosphatase Targeting to Glycogen, Protein Phosphatase Inhibitor-1, and Glycogenin

摘要

The finding of a reduced insulin-stimulated glucose uptake and glycogen synthesis in the skeletal muscle of glucose-tolerant first-degree relatives of patients with NIDDM, as well as in cultured fibroblasts and skeletal Muscle cells isolated from NIDDM patients, ahs been Interpreted as evidence for a genetic involvement in The disease. The mode of inheritance of the common Forms of NIDDM is as yet unclear, but the prevailing Hypothesis supports a polygenic model. In the present Study, we tested the hypothesis that the putative inher- Itable defects of insulin-stimulated muscle glycogen Synthesis might be caused by genetic variability in the Genes encoding proteins shown by biochemical evidence To be involved in insulin-stimulated glycogen synthesis In skeletal muscle.