Rapid Publication: Leptin Promotes Aggregation of Human Platelets Via the Long Form of Its Receptor

摘要

Plasma leptin levels are elevated in most obese indi- viduals, and obesity is accompanied by a high incidence of cardiovascular disease. Therefore, leptin could be involved in the pathogenesis of cardiovascular disease. In the present study, the role of leptin was explored in The regulation of platelet function. The expression of The long form of the leptin receptor was detected in Human platelets. At 50 ng/ml, human leptin induced Phosphorylatio of several proteins of platelets at the Tyrosine residue. Neither leptin at concentrations≥100 Ng/ml nor ADP at concentrations≥1 μmol/l affected Platelet aggregation.