Absolute Requirement of Macrophages for the Development and Activation of β-Cell Cytotoxic CD8+ T-Cells in T-Cell Receptor Transgenic NOD Mice

摘要

The development of autoimmune diabetes in NOD mice results from selective destruction of β-cells by a T- cell-dependent autoimmune process. However, the mechanisms that control the generation of β-cell cyto- toxic T-cells inv vivo are poorly understood. We recently established 8.3-T-cell receptor (TCR)-β transgenic NOD mice that show a selective acceleration of the Recruitment of CD8+ T-cells into the islets of prediabetic Animals, resulting in rapid β-cell restruction and early Onset of diabetes. This study was initiated to deter- Mine the role of macrophages in the development and Activation of diabetogenic CD8+ T-cells in 8.3-TCR-β Transgenic NOD mice.