Metformin Reduces Systemic Methylglyoxal Levels in Type 2 Diabetes

摘要

Methylglyoxal (MG) is a reactive α-dicarbonyl that is thought to contribute to diabetic complications either as a direct toxin or as a precursor for advanced glyca- tion end products. It is produced primarily from triose phosphates and is detoxified to D-lactate (DL) by the glyoxalase pathway. Because guanidino compounds can block dicarbonyl groups, we have investigated the effects of the diamino biguanide compound metformin and of hyperglycemia on MG and its detoxification products in type 2 diabetes. MG and DL were measured by high-performance liquid chromatography in plasma from 57 subjects with type 2 diabetes.