Non-Major Histocompatibility Complex-Linked Diabetes Susceptibility Loci on Chromosomes 4 And 13 in a Backcross of the DP-BB-Wor Rat To the WF Rat

摘要

BB rats are used as models of autoimmune human IDDM. Genetic control of IDDM in both species is com- Plex, including both major histocompatibility complex- (MHC)-linkd and non-MHC-linked genes. DP-BB rats develop IDDM spontaneously. Expression of disease in these animals requires homozygosity at the lyp locus, which causes lymphopenia. All genetic analyses of BB rat diabetes to date have backcrossed to the DP-BB strain or used (DP-BB×non-BB)F2 animals to ensure that a fraction of progeny are homozygous for lyp. Here we report the analysis of a backcross of the DP-BB rat to the histocompatible WF rat.