Rapid Publication: Plasma Triglyceride Reduction in Mice After Direct Injections of Muscle-Specific Lipoprotein Lipase DNA

摘要

The present study was conducted to determine if direct injections of plasmid pMCKhLPL DNA would led to suf- ficient overexpression of lipoprotein lipase (LPL) to reduce plasma triglycerides in mice. After single intra- muscular (IM) injections, human lipoprotein lipase (hLPL) mRNA was detectable in the quadriceps muscle for at least 21 days. Repeated intraperitoneal (IP) and IM DNA administration increased the LPL activity in Skeletal muscle by 58/100 (IP) and 36/100 (IM) when com- Pared with control-injected mice.