Trp64Arg Mutation of β_3-Adrenoceptor Gene Deteriorates Lipolysis Induced by β_3-Adrenoceptor Agonist in Human Omental Adipocytes

摘要

The recently described variant of the human β_3-adrener- gic receptor (AR) gene located mainly in visceral adipocytes is associated with earlier onset of NIDDM, abdominal obesity, insulin resistance, and an increased capacity to gain weight. We investigated whether lipoly- sis in human omental adipocytes induced by a potent and selective human β_3-AR agonist (L-755, 507) was affected by the Trp64Arg mutation of the β_3-adrenoceptor, using 18 omental fat samples obtained during total hysterec- tomy.