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[beta]-Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform

机译:肝胰岛素抵抗诱导的β-细胞增生:肝-胰腺内分泌轴通过胰岛素受体A同工型的作用

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摘要

Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible liver-specific insulin receptor knockout mouse (iLIRKO).
机译:2型糖尿病是由胰岛素抵抗和胰岛素分泌受损共同导致的。为了直接解决成年动物肝胰岛素抵抗的影响,我们开发了一种诱导型肝特异性胰岛素受体敲除小鼠(iLIRKO)。

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  • 来源
    《Diabetes》 |2009年第4期|p.820-828|共9页
  • 作者单位

    Oscar Escribano,1,2 Carlos Guillen,1,2 Carmen Nevado,1,2 Almudena Gómez-Hernández,1,2 C. Ronald Kahn,3 and Manuel Benito1,2From the 1 Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain, 2CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain, and the 3Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.Corresponding author Manuel Benito, benito@farm.ucm.es.Received 23 April 2008 and accepted 4 January 2009.Published ahead of print at http://diabetes.diabetesjournals.org on 9 January 2009. DOI: 10.2337/db08-0551.© 2009 by the American Diabetes Association. Readers may use ttiis article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:50

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