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首页> 外文期刊>Diabetes >Protein Farnesylation-Dependent Raf/Extracellular Signal-Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic [beta]-Cells
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Protein Farnesylation-Dependent Raf/Extracellular Signal-Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic [beta]-Cells

机译：蛋白法呢基化依赖性Raf /细胞外信号相关激酶信号转导与细胞骨架重塑，以促进葡萄糖诱导的胰腺β-细胞的胰岛素分泌。

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摘要

Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellular signal-related kinase (ERK1/2) signaling pathway in glucose-induced Rac1 activation and insulin secretion in the pancreatic beta-cell.
机译：小G蛋白的翻译后异戊酸酯化（例如，法呢基化）被认为是细胞骨架重塑以及分泌性囊泡与质膜融合的必要条件。在这里，我们调查了蛋白法尼基化在涉及Raf-1 /细胞外信号相关激酶（ERK1 / 2）信号传导途径的信号传导步骤中在葡萄糖诱导的Rac1活化和胰腺β细胞中胰岛素分泌中的作用。

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  • 来源
    《Diabetes》 |2010年第4期|p.967-977|共11页
  • 作者

    Anjaneyulu Kowluru Rajakrishnan Veluthakal Christopher J Rhodes Vasudeva Kamath Ismail Syed Brandon J Koch;

  • 作者单位

    Anjaneyulu Kowluru,1 Rajakrishnan Veluthakal,1 Christopher J. Rhodes,2 Vasudeva Kamath,1 Ismail Syed,1 and Brandon J. Koch1From the 'Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University and ß-Cell Biochemistry Laboratory, John D. Dtngell VA Medical Center, Detroit, Michigan, and the ^Kovler Diabetes Center, Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, Illinois.Corresponding author. Anjaneyulu Kowluru, akowIuru@med.wayne.edu.Received 8 September 2009 and accepted 4 January 2010. Published ahead of print at http://diabetes.diabetesjournals.org on 13 January 2010. DOI, 10.2337/db09-1334.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this art irle were defrayed in part by the payment of page charges. This artici* must therefore be lieivby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-17 13:45:40

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