Sulfonylurea Receptor 1 and Kir6.2 Expression in the Novel Human Insulin-Secreting Cell Line NES2Y

摘要

NES2Y is a proliferating human insulin-secreting cell line that well have derived from a patient with persistent hyperinsulinemic hypoglycemia of infancy. This disease is characterized by unregulated insulin release despite profound hypoglycemia. NES2Y cells, like β-cells iso- lated form the patient of origin, lack functional ATP- sensitive potassium channels (K)ATP) and also carry a defect in the insulin gene-regulatory transcription fac- tor PDX1.