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Systemic Free Fatty Acid Disposal Into Very Low-Density Lipoprotein Triglycerides

机译:将全身性脂肪酸处置到极低密度脂蛋白甘油三酸酯中

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摘要

We measured the incorporation of systemic free fatty acids (FFA) into circulating very low-density lipoprotein triglycerides (VLDL-TGs) under postabsorptive, postprandial, and walking conditions in humans. Fifty-five men and 85 premenopausal women with BMI 18-24 (lean) and 27-36 kg/m2 (overweight/obese) received an intravenous bolus injection of [1,1,2,3,3-~2H_5]glycerol (to measure VLDL-TG kinetics) and either [1-~(14)C]palmitate or [9,10-~3H] patmitate to determine the proportion of systemic FFA that is converted to VLDL-TG. Experiments started at 0630 h after a 12-h overnight fast. In the postabsorptive protocol, participants rested and remained fasted until 1330 h. In the postprandial protocol, volunteers ingested frequent portions of a fat-free smoothie. In the walking protocol, participants walked on a treadmill for 5.5 h at ~3× resting energy expenditure. Approximately 7% of circulating FFA was converted into VLDL-TG. VLDL-TG secretion rates (SRs) were not statistically different among protocols. Visceral fat mass was the only independent predictor of VLDL-TG secretion, explaining 33-57% of the variance. The small proportion of systemic FFA that is converted to VLDL-TG can confound the expected relationship between plasma FFA concentration and VLDL-TG SRs. Regulation of VLDL-TG secretion is complex in that, despite a broad spectrum of physiological FFA concentrations, VLDL-TG SRs did not vary based on different acute substrate availability.
机译:我们测量了人体在吸收后,餐后和步行条件下将系统性游离脂肪酸(FFA)掺入循环中的低密度脂蛋白甘油三酸酯(VLDL-TGs)中的情况。 55名BMI 18-24(瘦)和27-36 kg / m2(超重/肥胖)的男性和85名绝经前妇女接受了静脉内推注[1,1,2,3,3-〜2H_5]甘油(以测定VLDL-TG动力学)和[1-〜(14)C]棕榈酸酯或[9,10-〜3H]棕榈酸酯来确定转化为VLDL-TG的全身FFA的比例。禁食12小时后,于0630小时开始实验。在吸收后方案中,参与者休息并禁食直至1330 h。在餐后方案中,志愿者经常摄入无脂奶昔​​。在步行方案中,参与者以约3倍的静态能量消耗在跑步机上行走5.5 h。约7%的循环FFA转化为VLDL-TG。协议之间的VLDL-TG分泌率(SR)没有统计学差异。内脏脂肪量是VLDL-TG分泌的唯一独立预测因子,解释了33-57%的差异。全身性FFA转化为VLDL-TG的比例很小,可能会混淆血浆FFA浓度与VLDL-TG SR之间的预期关系。 VLDL-TG分泌的调节很复杂,因为尽管生理FFA浓度范围很广,但VLDL-TG SR并不会因不同的急性底物可用性而变化。

著录项

  • 来源
    《Diabetes》 |2013年第7期|2386-2395|共10页
  • 作者单位

    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota;

    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota;

    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota;

    Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri;

    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 03:46:24

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