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Circadian Regulation of Lipid Mobilization in White Adipose Tissues

机译:白色脂肪组织中脂质动员的昼夜节律

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摘要

In mammals, a network of circadian clocks regulates 24-h rhythms of behavior and physiology. Circadian disruption promotes obesity and the development of obesity-associated disorders, but it remains unclear to which extent peripheral tissue clocks contribute to this effect. To reveal the impact of the circadian timing system on lipid metabolism, blood and adipose tissue samples from wild-type, ClockA19, and Bmall~(-/-) circadian mutant mice were subjected to biochemical assays and gene expression profiling. We show diurnal variations in lipolysis rates and release of free fatty acids (FFAs) and glycerol into the blood correlating with rhythmic regulation of two genes encoding the lipolysis pacemaker enzymes, adipose triglyceride (TG) lipase and hormone-ensitive lipase, by self-sustained adipocyte clocks. Circadian clock mutant mice show low and nonrhythmic FFA and glycerol blood content together with decreased lipolysis rates and increased sensitivity to fasting. Instead circadian clock disruption promotes the accumulation of TGs in white adipose tissue (WAT), leading to increased adiposity and adipocyte hypertrophy. In summary, circadian modulation of lipolysis rates regulates the availability of lipid-derived energy during the day, suggesting a role for WAT clocks in the regulation of energy homeostasis.
机译:在哺乳动物中,生物钟的网络调节行为和生理的24小时节律。昼夜节律紊乱促进肥胖症和肥胖症相关疾病的发展,但尚不清楚外周组织钟在多大程度上促成这种作用。为了揭示昼夜节律对脂肪代谢的影响,对野生型,ClockA19和Bmall〜(-/-)昼夜节律突变小鼠的血液和脂肪组织样品进行了生化分析和基因表达谱分析。我们显示出脂解速率的日变化以及游离脂肪酸(FFA)和甘油释放到血液中与通过自我维持而编码的两个编码脂解起搏酶,甘油三酸酯(TG)脂肪酶和激素敏感型脂肪酶的基因的节律调节相关脂肪细胞时钟。昼夜节律时钟变体小鼠显示出低和非节律的FFA和甘油血含量,同时脂解速率降低,对禁食的敏感性增加。相反,昼夜节律的破坏会促进TG在白色脂肪组织(WAT)中的积累,从而导致肥胖和脂肪细胞肥大。总而言之,昼夜节律对脂肪分解速率的调节可调节白天源自脂质的能量的可用性,这表明WAT时钟在能量稳态中的作用。

著录项

  • 来源
    《Diabetes》 |2013年第7期|2195-2203|共9页
  • 作者单位

    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany;

    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany;

    Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany,Medical Department I, University of Luebeck, Luebeck, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 03:46:26

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