What's the Time? Does the Artificial Pancreas Need to Know?

摘要

The development of a closed-loop artificial pancreas (AP) represents a major technological effort that aims to improve glucose control, prevent complications, and decrease disease burden for patients with diabetes. An AP consists of three components: i) a subcutaneous glucose monitor, 2) a subcutaneous insulin pump, and 3) an automated control algorithm (Fig. 1) (1,2). Until recently, clinical trials investigating AP function were limited to controlled, in-hospital settings (1,3). However, several recent studies showed that an AP can maintain (4) or even improve (5) glycemic control outside of the hospital.