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Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

机译:齐墩果酸及相关五环三萜类化合物的降糖活性的生化基础

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摘要

Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic syndrome. It improves insulin response, preserves functionality and survival of β-cells, and protects against diabetes complications. OA may directly modulate enzymes connected to insulin biosynthesis, secretion, and signaling. However, its major contributions appear to be derived from the interaction with important transduction pathways, and many of its effects are consistently related to activation of the transcription factor Nrf2. Doing that, OA induces the expression of antioxidant enzymes and phase Ⅱ response genes, blocks NF-kB, and represses the polyol pathway, AGEs production, and hyperlipidemia. The management of type 2 diabetes requires an integrated approach, which includes the early intervention to prevent or delay the disease progression, and the use of therapies to control glycemia and lipidemia in its late stages. In this sense, the use of functional foods or drugs containing OA is, undoubtedly, an interesting path.
机译:齐墩果酸(OA)是许多植物性食品和草药的天然成分,具有广泛的药理特性,其治疗潜力直到现在还只有部分被开发出来。在复杂的多因素机制中,OA对糖尿病和代谢综合症发挥有益作用。它改善胰岛素反应,保留β细胞的功能和存活率,并预防糖尿病并发症。 OA可以直接调节与胰岛素生物合成,分泌和信号传导有关的酶。但是,它的主要贡献似乎来自与重要转导途径的相互作用,并且其许多作用始终与转录因子Nrf2的激活有关。这样做,OA可以诱导抗氧化酶和Ⅱ期响应基因的表达,阻断NF-kB,并抑制多元醇途径,AGEs的产生和高脂血症。 2型糖尿病的治疗需要综合的方法,包括早期干预以预防或延缓疾病进展,以及在晚期使用治疗手段控制血糖和血脂。从这个意义上讲,使用功能性食品或含有OA的药物无疑是一条有趣的道路。

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  • 来源
    《Diabetes》 |2013年第6期|1791-1799|共9页
  • 作者单位

    From the Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Seville, Spain;

    From the Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Seville, Spain;

    From the Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Seville, Spain;

    From the Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Seville, Spain;

    From the Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Seville, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 03:46:25

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