Mathematical Modelling of Non-Linear Solvent-Gradient Simulated Moving Bed Chromatographic Separation Processes

摘要

The solvent-gradient operation mode exploited within simulated moving bed (SMB) chromatographic separation processes can be used to improve the efficiency of separations. A detailed model that takes into account non-linear isotherms, solvent gradient, mass transfer resistance, and the discrete event of port periodic switching, was developed in order to simulate the complex dynamics. All design parameters (number, configuration, length and diameter of columns, particle size) and operating parameters (switching period, flow rates of feed, raffinate, desorbent, extract and recycling flow, feed concentrations, different volume fraction of the weak solvent in desorbent and feed) can be chosen correctly by numerical simulation. This model can facilitate the design, operation, optimization, control and scale-up of the non-linear solvent-gradient SMB (SG-SMB) units.