首页> 外文期刊>American Journal of Biomedical and Life Sciences >The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats
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The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats

机译:心肌圆顶甲醇烯醇螺母提取物在链脲佐菌素诱导的糖尿病大鼠中的低血糖,抗高脂肪动物和抗氧化作用

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This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 25030g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (p0.05) the fasting blood glucose level, oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) concentrations and significantly increase (p0.05) the high-density lipoprotein (HDL) in diabetic treated rats. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Reduced glutathione (GSH), and Catalase (CAT) levels significantly (p0.05) increases with a decrease Malondialdehyde (MDA) level in diabetic treated rats. Food intake and bodyweight of diabetic treated rats significantly increases (p0.05). Markers of liver and kidney functions were also improved in diabetic treated rats. The results from this study suggest that Anacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications.
机译:该研究工作研究了抗糖尿病,抗高脂肪血症和胰腺炎植物型甲醇螺母提取物在链脲佐菌素诱导的糖尿病Wistar大鼠中的抗氧化作用。重量25030g的400(40)只大鼠随机分为5组8rats。 Group1成为控制;患有糖尿病诱导的糖尿病患者,单剂量为50mg / kgbw腹腔内腹腔内。糖尿病诱导后,Group2仅作为链脲佐菌素,分别施用1100mg / kgbw和200mg / kgbwp.o,螺旋螺母提取物,而Group5作为参考药物施用2mg / kgbw,作为参考药物,为4周的一段时间。 。每日监测食品和水摄入量,体重和血糖在整个实验中每周监测。在Day29中,处死动物,通过心脏穿刺来收集血液样品进行生化研究。奥卡达米螺母提取物的施用显着降低(P <0.05)空腹血糖水平,口服葡萄糖耐量试验(OGTT),甘油三酯(TG),总胆固醇(TC),低密度脂蛋白(LDL),非常低 - 密度脂蛋白(VLDL)浓度和显着增加(P <0.05)糖尿病处理大鼠的高密度脂蛋白(HDL)。超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GPX),降低的谷胱甘肽(GSH)和过氧化氢酶(猫)水平显着(P <0.05)随着糖尿病处理大鼠的降低而增加。糖尿病治疗大鼠的食物摄入和体重显着增加(P <0.05)。糖尿病处理大鼠的肝肾功能标记也得到改善。本研究的结果表明,心绞痛螺母可用于糖尿病的治疗管理及其相关并发症。

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