Objectives: To investigate the effect of 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitor on bonemicrostructure and bone density in rats with femoral head necrosis. Methods: Eighty Sprague-Dawley (SD) rats wereselected and randomly divided into two groups. One group was selected for femoral head necrosis modeling. Then themodeled rats were randomly divided into two groups, one group was injected with 11β-HSD1 inhibitor as the treatmentgroup, and the other group was used as the model. The unmodeled rats were also randomly divided into two groups, onegroup was injected with 11β-HSD1 inhibitor as the control group, and the other group was taken as the normal group.The bone microstructure and femoral bone density of 4 groups of rats were observed. Results: There were no significantdifferences in bone microstructure and bone density between the treatment group and the model group before injection (P0.050), but they were significantly improved after injection (P0.050). SOD increasedsignificantly, and MDA decreased significantly after injection in the treatment group (P0.001). Conclusions: 11β-HSD1inhibitor can effectively improve the bone microstructure of femoral head necrosis rats and increase bone density, whichcan be used as a new scheme for the treatment of femoral head necrosis in the future.
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