More than 2/3 of patients with hypertension need drugs from more than 2 drug classes with different mechanisms to achieve control of hypertension.1-4) Combination therapy is particularly helpful for patients receiving prolonged blood pressure treatment, and highrisk patients.5) Because recent hypertension guidelines recommends more intensive blood pressure control,6) most hypertensive patients require drug combination.7)8) Combination therapy is more effective than single-drug therapy at a higher dose. Therefore 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guideline even recommends dual combination treatment as initial therapy in most hypertensive patients rather than monotherapy.
展开▼
