The aim of the study was to investigate the chemopreventive potential of andrographolide in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors developed in the buccal pouch of golden Syrian hamsters at a 100% incidence on painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Marked abnormalities in the status of detoxification enzymes, lipid perxodiation and antioxidants were noticed in hamsters treated with DMBA alone. Oral administration of andrographolide at a dose of 50 mg/kg bw to hamsters treated with DMBA not only completely prevented the tumor formation but also restored the status of the above mentioned biomarkers. The present study thus demonstrates the chemopreventive potential of andrographolide in DMBA-induced hamster buccal pouch carcinogenesis, which is probably due to its antioxidant potential as well as modulating effect on xenobiotic metabolising enzymes during DMBA-induced oral carcinogenesis.
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机译：该研究的目的是探讨Andrographolide在7,12-二甲基（A）蒽（DMBA）的化学预防潜力 - 诱导的仓鼠颊囊癌发生。口腔肿瘤在金叙利亚仓鼠的口腔袋中开发，在100％的发病率，在液体石蜡中涂在0.5％DMBA，每周3次14周。在用DMBA处理的仓鼠中，注意到解毒酶状况，脂质破旧和抗氧化剂的状态的标记异常。口服给予Andrographolide的剂量为50mg / kg Bw到用DMBA治疗的仓鼠，不仅完全阻止了肿瘤形成，还恢复了上述生物标志物的状态。因此，本研究证明了DMBA诱导的仓鼠颊囊癌生殖器中的Androhogholide的化学预防潜力，这可能是由于其抗氧化潜力以及在DMBA诱导的口腔致癌中对异黄素代谢酶的调节作用。
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