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Effect of Hydroxyurea Treatment on the Inflammatory Markers Among Children With Sickle Cell Disease

机译:羟基脲处理对镰状细胞疾病儿童炎症标志物的影响

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Background: Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential inflammatory marker in sickle cell disease (SCD). This study aimed to evaluate the impact of hydroxyurea (HU) treatment on the value of NLR and some inflammatory mediators in SCD. Methods: The hematological parameters and clinical events were analyzed in 35 children with SCD under HU treatment and followed up for 1 year and in 20 healthy controls. Enzyme-linked immunosorbent assay was performed for the evaluation of proinflammatory cytokines, including interleukin (IL) 6, IL-8, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor α (TNF-α). Results: Hydroxyurea significantly improves most of the hematological parameters in children with SCD. The percentages of hemoglobin fraction S, serum levels of TNF-α and IL-6 were significantly decreased when compared to baseline value but did not reach the value of the healthy control. The HU treatment led to a significant decrease in NLR compared to the baseline values and reached healthy control values. Neutrophil-to-lymphocyte ratio was positively correlated with hs-CRP, TNF-α, and IL-8 serum levels and negatively correlated with percentage of fetal hemoglobin and hematocrit values. The cutoff value of NLR to expect a response to HU among SCD was 3.0, with 76% specificity and 85% sensitivity (area under the curve: 0.85, P .0001). In conclusion, hydroxyurea induced a decrease in NLR and inflammatory cytokines, which represent a biomarker of inflammation in SCD. The calculation of NLR is a straightforward and cheap method for SCD outcome prediction in young children.
机译:背景:在镰状细胞疾病(SCD)中引入中性粒细胞至淋巴细胞比(NLR)作为潜在的炎症标志物。本研究旨在评估羟基脲(Hu)处理对SCD中NLR和一些炎症介质的影响。方法:在35例SCD治疗中分析血液学参数和临床事件,随访1年,并在20例健康对照。对酶联免疫吸附测定进行用于评估促炎细胞因子,包括白细胞介素(IL)6,IL-8,高敏感性C-反应蛋白(HS-CRP)和肿瘤坏死因子α(TNF-α)。结果:羟基脲显着改善了SCD中儿童的大部分血液学参数。与基线值相比,血红蛋白级分,TNF-α和IL-6的血清水平的百分比显着降低,但未达到健康对照的价值。与基线值相比,HU处理导致NLR的显着降低,并达到了健康的对照值。中性粒细胞到淋巴细胞比与HS-CRP,TNF-α和IL-8血清水平正相关,并与胎儿血红蛋白和血细胞比容值的百分比负相关。 NLR的截止值期望SCD中Hu的反应为3.0,特异性76%和85%的灵敏度(曲线下面积:0.85,P <.0001)。总之,羟基脲诱导NLR和炎性细胞因子的降低,这代表了SCD中炎症的生物标志物。 NLR的计算是幼儿SCD结果预测的简单和廉价的方法。

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