Complete synthesis of 3′‐sialyl‐N‐acetyllactosamine by regioselective transglycosylation

摘要

>Transglycolytic synthesis of 3′-sialyl-N-acetyllactosamine by sequential use of β-galactosidase from Bacillus circulans and trans-sialidase from Trypanosoma cruzi was described. These reactions depicted the first complete synthesis of a biologically important oligosaccharide with high regioselectivity avoiding use of glycosyltransferases and NDP sugars.