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Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study

机译:肥胖,糖尿病父母史和2型糖尿病基因的影响:病例对照研究

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Obesity, parental history (PH) of type 2 diabetes (T2D), and genes play an important role in T2D development. However, the influence of each factor on T2D variability is unclear. This study aimed to investigate the influence of obesity (body mass index [BMI], waist/hip ratio), PH, and 16 single-nucleotide polymorphisms (SNPs) associated with T2D on T2D variability in Mexico, comparing 1234 non-diabetic controls and 1219 diabetic patients. To replicate the data, a case-control (n?=?2904) and a cross-sectional (n?=?1901) study were also included. In a multivariate logistic regression model, all factors accounted for only 27.3% of T2D variability: SNPs (8.4%); PH (11.8%) and obesity (7.1%). These factors contributed more in men (33.2%) than in women (25%), specifically when the disease was diagnosed before the age of 46 (46.7% vs. 30%). Genes played a substantially more important role in men than in women (14.9% vs. 5.5%), while obesity and PH played a similar role in both genders. Genes and PH appeared to play a greater role than obesity in T2D. However, obesity contribution was calculated at the time of recruitment and may be underestimated in patients because the BMI decreased linearly with the number of years with the disease. The data suggest that sexual hormones may play important roles in genes that are associated with T2D.
机译:肥胖,2型糖尿病(T2D)的父母病史(PH)和基因在T2D的发展中起重要作用。但是,尚不清楚每个因素对T2D变异性的影响。这项研究旨在调查肥胖(体重指数[BMI],腰围/臀围比率),PH和16种与T2D相关的单核苷酸多态性(SNP)对墨西哥T2D变异性的影响,比较了1234名非糖尿病对照和1219名糖尿病患者。为了复制数据,还包括病例对照研究(n≥2904)和横截面研究(n≥1901)。在多元逻辑回归模型中,所有因素仅占T2D变异性的27.3%:SNP(8.4%); PH(11.8%)和肥胖(7.1%)。这些因素在男性(33.2%)中的贡献要大于女性(25%),特别是在46岁之前诊断出该疾病时(46.7%对30%)。基因在男性中的作用远比女性重要(14.9%对5.5%),而肥胖和PH在两种性别中的作用相似。在T2D中,基因和PH似乎比肥胖发挥更大的作用。但是,肥胖的贡献是在招募时计算出来的,在患者中可能被低估了,因为BMI随疾病年限的增加而线性下降。数据表明,性激素可能在与T2D相关的基因中起重要作用。

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