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The Association between Cannabis Product Characteristics and Symptom Relief

机译:大麻产品特征与症状缓解之间的关联

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Federal barriers and logistical challenges have hindered measurement of the real time effects from the types of cannabis products used medically by millions of patients in vivo. Between 06/06/2016 and 03/05/2018, 3,341 people completed 19,910 self- administrated cannabis sessions using the mobile device software, ReleafApp to record: type of cannabis product (dried whole natural Cannabis flower, concentrate, edible, tincture, topical), combustion method (joint, pipe, vaporization), Cannabis subspecies (C. indica and C. sativa), and major cannabinoid contents (tetrahydrocannabinol, THC; and cannabidiol, CBD), along with real-time ratings of health symptom severity levels, prior-to and immediately following administration, and reported side effects. A fixed effects panel regression approach was used to model the within-user effects of different product characteristics. Patients showed an average symptom improvement of 3.5 (SD?=?2.6) on an 11-point scale across the 27 measured symptom categories. Dried flower was the most commonly used product and generally associated with greater symptom relief than other types of products. Across product characteristics, only higher THC levels were independently associated with greater symptom relief and prevalence of positive and negative side effects. In contrast, CBD potency levels were generally not associated with significant symptom changes or experienced side effects.
机译:联邦壁垒和后勤方面的挑战已阻碍了对数百万患者体内使用的医用大麻产品类型的实时影响的测量。 2016年6月6日至2018年3月5日之间,有3,341人使用移动设备软件ReleafApp完成了19,910次自我管理的大麻会议,记录:大麻产品的类型(干燥的天然大麻干花,浓缩液,食用,tin剂,局部用药) ),燃烧方法(接头,管道,蒸发),大麻亚种(印度。和苜蓿)以及主要大麻素含量(四氢大麻酚,四氢大麻酚和大麻二酚,CBD),以及对健康症状严重程度的实时评估,给药前和给药后立即发生副作用。固定效果小组回归方法用于对不同产品特征的用户内部效果进行建模。患者在27种已测症状类别中的11点量表上平均症状改善为3.5(SD?=?2.6)。干花是最常用的产品,通常比其他类型的产品具有更大的症状缓解效果。在所有产品特征中,只有较高的四氢大麻酚含量才与症状缓解和阳性和阴性副作用的发生率独立相关。相反,CBD效力水平通常与明显的症状变化或未经历的副作用无关。

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