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MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli

机译:MAOA变异体在对诱发攻击的刺激做出反应时,脑电图和心电图的活动有所不同

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Among the genetic variations in the monoamine oxidase A (MAOA) gene, upstream variable?number tandem repeats (uVNTRs) of the promoter have been associated with individual differences in human physiology and aggressive behaviour. However, the evidence for a molecular or neural link between MAOA uVNTRs and aggression remains ambiguous. Additionally, the use of inconsistent promoter constructs in previous studies has added to the confusion. Therefore, it is necessary to demonstrate the genetic function of MAOA uVNTR and its effects on multiple aspects of aggression. Here, we identified three MAOA alleles in Koreans: the predominant 3.5R and 4.5R alleles, as well as the rare 2.5R allele. There was a minor difference in transcriptional efficiency between the 3.5R and 4.5R alleles, with the greatest value for the 2.5R allele, in contrast to existing research. Psychological indices of aggression did not differ among MAOA genotypes. However, our electroencephalogram and electrocardiogram results obtained under aggression-related stimulation revealed oscillatory changes as novel phenotypes that vary with the MAOA genotype. In particular, we observed prominent changes in?frontal γ power and heart rate in 4.5R carriers of men. Our findings provide genetic insights into MAOA function and offer a neurobiological basis for various socio-emotional mechanisms in healthy individuals.
机译:在单胺氧化酶A(MAOA)基因的遗传变异中,启动子的上游可变数目串联重复序列(uVNTR)与人类生理和攻击行为的个体差异有关。然而,关于MAOA uVNTR与攻击之间存在分子或神经联系的证据仍然不明确。另外,先前研究中不一致的启动子构建体的使用增加了混乱。因此,有必要证明MAOA uVNTR的遗传功能及其对侵略行为的多个方面的影响。在这里,我们确定了韩国人中的三个MAOA等位基因:主要的3.5R和4.5R等位基因,以及罕见的2.5R等位基因。与现有研究相反,在3.5R和4.5R等位基因之间的转录效率存在微小差异,其中2.5R等位基因的价值最大。攻击心理指标在MAOA基因型之间没有差异。然而,我们的脑电图和心电图结果在攻击性相关刺激下显示出振荡变化,这是随MAOA基因型而变化的新表型。特别是,我们观察到男性4.5R携带者的额叶γ功率和心率显着变化。我们的发现提供了对MAOA功能的遗传见解,并为健康个体的各种社会情感机制提供了神经生物学基础。

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