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DNA methylation of dopamine-related gene promoters is associated with line bisection deviation in healthy adults

机译:多巴胺相关基因启动子的DNA甲基化与健康成年人的线平分偏差相关

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Handedness and language lateralization are the most investigated phenotypes among functional hemispheric asymmetries, i.e. differences in function between the left and the right half of the human brain. Both phenotypes are left hemisphere-dominant, while investigations of the molecular factors underlying right hemisphere-dominant phenotypes are less prominent. In the classical line bisection task, healthy subjects typically show a leftward attentional bias due to a relative dominance of the right hemisphere for visuospatial attention. Based on findings of variations in dopamine-related genes affecting performance in the line bisection task, we first tested whether DNA methylation in non-neuronal tissue in the promoter regions of DBH, SLC6A3, and DRD2 are associated with line bisection deviation. We replicated the typical behavioral pattern and found an effect of DNA methylation in the DBH promoter region on line bisection deviation in right-aligned trials. A second exploratory analysis indicated that an overall DNA methylation profile of genes involved in dopamine function predicts line bisection performance in right-aligned trials. Genetic variation in dopamine-related genes has been linked to attention deficit hyperactivity disorder (ADHD), a neurodevelopmental trait associated with rightward attentional bias. Overall, our findings point towards epigenetic markers for functional hemispheric asymmetries in non-neuronal tissue not only for left hemisphere-dominant, but also for right hemisphere-dominant phenotypes.
机译:在功能性半球不对称性中,惯用性和语言偏侧化是研究最多的表型,即人脑左右一半之间的功能差异。两种表型均以左半球为主导,而对右半球为主导的表型的分子因素研究较少。在经典的二等分任务中,由于右半球对视觉空间注意力的相对优势,健康的受试者通常表现出向左的注意偏见。基于多巴胺相关基因变异影响线平分任务性能的发现,我们首先测试了DBH,SLC6A3和DRD2启动子区域中非神经组织中的DNA甲基化是否与线平分偏差相关。我们复制了典型的行为模式,并在右对齐试验中发现了DBH启动子区域DNA甲基化对线二等分偏差的影响。第二次探索性分析表明,与多巴胺功能有关的基因的总体DNA甲基化谱可预测右对齐试验中的线对分表现。多巴胺相关基因的遗传变异与注意力缺陷多动障碍(ADHD)有关,注意力缺陷多动障碍是一种与右倾注意偏见相关的神经发育特征。总的来说,我们的发现指向非神经组织中功能性半球不对称的表观遗传标记,不仅针对左半球占主导地位,而且针对右半球占主导地位的表型。

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