Specific inhibition of triiodothyronine-induced tadpole tail-fin regression by cathepsin D-inhibitor pepstatin

Hiroshi Seshimo; Masashi Ryuzaki; Katsutoshi Yoshizato

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Specific inhibition of triiodothyronine-induced tadpole tail-fin regression by cathepsin D-inhibitor pepstatin

机译：组织蛋白酶D抑制剂胃抑素对三碘甲状腺素诱导的t尾鳍消退的特异性抑制

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Explantsoftail-fintissuefromRanacatesbeianatadpolewereculturedinHanks'balancedsaltsolutionat22?°Cwithtriiodothyronine(T3)andinhibitorsofproteolyticenzymesinordertodeterminewhethersomeinhibitor(s)couldabolishtheregressionoftail-fininducedbyT3.Inhibitorsofmicrobialorigin,leupeptin,antipain,chymostatin,andpepstatin,werestudied.Oftheseproteinaseinhibitors,onlypepstatinwasfoundtobeeffectiveinblockingtheactionofthehormone,inadose-responsemanner.Theresultsstronglysuggestthatpepstatin-sensitiveacidprotease(s),includingcathepsinD,mightbeinvolvedinT3-inducedtail-findegradation.

机译：Explantsoftail-fintissuefromRanacatesbeianatadpolewereculturedinHanks＆＃X27; balancedsaltsolutionat22°Cwithtriiodothyronine（T3）andinhibitorsofproteolyticenzymesinordertodeterminewhethersomeinhibitor（S）couldabolishtheregressionoftail-fininducedbyT3.Inhibitorsofmicrobialorigin，亮抑酶肽，抗蛋白酶，胰凝乳蛋白酶抑制剂，andpepstatin，werestudied.Oftheseproteinaseinhibitors，onlypepstatinwasfoundtobeeffectiveinblockingtheactionofthehormone，inadose-responsemanner.Theresultsstronglysuggestthatpepstatin-sensitiveacidprotease（S），includingcathepsinD，可能与T3诱导的尾鳍降解有关。

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《Developmental biology》 |1977年第1期|共页
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Hiroshi Seshimo; Masashi Ryuzaki; Katsutoshi Yoshizato;
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中图分类生物科学;
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1. Inhibition of the Cathepsin D-Type Proteinase of Macrophages by Pepstatin, a Specific Pepsin Inhibitor, and Other Substances [J] . Martha H. McAdoo, Arthur M. Dannenberg, Cara J. Hayes, Infection and immunity . 1973,第4期

机译：胃蛋白酶，一种特定的胃蛋白酶抑制剂和其他物质对巨噬细胞的组织蛋白酶D型蛋白酶的抑制作用
2. Poly (A)-Containing RNA Synthesis in Cultured Xenopus laevis Tadpole Tail during Triiodothyronine-Induced Regression [J] . Akira Kawahara, Kiyotaka Yamana Cell structure and function . 1977,第3期

机译：Triiodothyronine引起的退化过程中培养非洲爪蟾Ta尾中的含聚（A）RNA合成。
3. Molecular Dynamics and Free Energy Analyses of Cathepsin D-Inhibitor Interactions: Insight into Structure-Based Ligand Design [J] . Shuanghong Huo, Junmei Wang, Piotr Cieplak, Journal of Medicinal Chemistry . 2002,第7期

机译：组织蛋白酶D抑制剂相互作用的分子动力学和自由能分析：基于结构的配体设计的见解。
4. Evaluation of the anti-hyperalgesic and anti-allodynic effects of cathepsin S inhibition in a murine model of neuropathic pain [C] . Hao J.-X., Xu X.-J., Wiesenfeld-Hallin Z., International Congress on Neuropathic Pain . 2010

机译：抗痛觉过敏和抗恶性对神经病疼痛小鼠模型中的抗痛觉痛经和抗恶性分解效应
5. Exploration of human cathepsin D specificity using native enzyme, A re-engineered recombinant model, and site-directed mutagenesis [D] . Beyer, Brian McFarren 1996

机译：探索人类组织蛋白酶D的特异性，使用天然酶，A重新设计的重组模型和定点诱变
6. Inhibition of the Cathepsin D-Type Proteinase of Macrophages by Pepstatin a Specific Pepsin Inhibitor and Other Substances [O] . Martha H. McAdoo, Arthur M. Dannenberg Jr., Cara J. Hayes, 1973

机译：胃蛋白酶抑制素一种特定的胃蛋白酶抑制剂和其他物质对巨噬细胞的组织蛋白酶D型蛋白酶的抑制作用。
7. Inhibition of the Cathepsin D-Type Proteinase of Macrophages by Pepstatin, a Specific Pepsin Inhibitor, and Other Substances [O] . Martha H. McAdoo, Arthur M. Dannenberg, Cara J. Hayes, 1973

机译：胃蛋白酶，特定的胃蛋白酶抑制剂和其他物质抑制巨噬细胞的组织蛋白酶D型蛋白酶
8. Inhibition of the Cathepsin D-Type Proteinase of Macrophages by Pepstatin, a Specific Pepsin Inhibitor, and Other Substances. [R] . McAdoo, M. H., Dannenberg, A. M., Hayes, C. J., 1972

机译：pepstatin，特异性胃蛋白酶抑制剂和其他物质对巨噬细胞组织蛋白酶D型蛋白酶的抑制作用。

Specific inhibition of triiodothyronine-induced tadpole tail-fin regression by cathepsin D-inhibitor pepstatin

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