首页>
外文期刊>The journal of immunology
>Differential Sensitivity of Bone Marrow and Thymus Cells to Actinomycin D in the in Vivo Response of Mice to Sheep Erythrocytes
【24h】
Differential Sensitivity of Bone Marrow and Thymus Cells to Actinomycin D in the in Vivo Response of Mice to Sheep Erythrocytes
Three cell types required for the hemolytic antibody response have been defined based upon their differential sensitivities to treatment with actinomycin D: a) the thymus-derived cell that is insensitive to treatment with 1.0 μg/ml of actinomycin; b) the antibody-forming precursor cell, of bone marrow origin, that is inhibited by 0.1 to 1.0 μg/ml of actinomycin and c) an auxiliary cell that is extremely sensitive to treatment with 0.01 μg/ml of actinomycin. Utilizing these sensitivities to actinomycin we determined the repopulation of each of the three cell types in the irradiated mouse spleen.
展开▼