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外文期刊>The biochemical journal
>Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations
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Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations
pThe syntheses of 10,11-dihydrobenz[ia/i]anthracene 8,9-oxide, benz[ia/i]anthracene 8,9-oxide and 9-hydroxybenz[ia/i]anthracene are described, together with those of a number of related compounds. The epoxides react both chemically and enzymically with water to yield the corresponding dihydrodiols and with reduced glutathione to form glutathione conjugates, and they react chemically with iN/i-acetylcysteine to yield the corresponding mercapturic acids. 8,9-Dihydro-8,9-dihydroxybenz[ia/i]anthracene, formed enzymically from benz[ia/i]anthracene 8,9-oxide, was identical with a dihydrodiol formed when benz[ia/i]anthracene was metabolized by rat liver homogenates. Similarly 10,11-dihydrobenz[ia/i]anthracene 8,9-oxide yielded a dihydrodiol identical with the product formed when 10,11-dihydrobenz[ia/i]anthracene was metabolized./p
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机译:> 10,11-二氢苯并[[i> a i>]蒽8,9-氧化物,苯并[[i> a i>]]蒽8,9-氧化物和9-羟基苯的合成[描述了[蒽]蒽,以及许多相关化合物的蒽。环氧化物与水发生化学和酶反应,产生相应的二氢二醇,并与还原的谷胱甘肽反应形成谷胱甘肽共轭物,并且它们与N i-乙酰基半胱氨酸化学反应产生相应的巯基酸。由苯并[[a]]蒽8,9-氧化物酶促形成的8,9-二氢-8,9-二羟基苯并[蒽]蒽与形成的二氢二醇相同当苯并[ a i>]蒽被大鼠肝脏匀浆代谢时。类似地,10,11-二氢苯并[[a]]蒽8,9-氧化物产生的二氢二醇与10,11-二氢苯并[[a]]蒽被代谢时形成的产物相同。 p>
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