Platelet and F-VIII reservoir and phagocytic function Of the spleen have been studied in 7 patients with Hb-S-thalassemia and 13 acute cases of Hb SS disease. 8 splenectomized patients and 11 healthy children served, as controls. F-VIII elevation following adrenalin was found to be a sensitive index in the evaluation of “functional hypersplenism” I which was shown in 42.8 and 77 % of the patients with Hb-S-β-thalassemia and Hb SS disease respectively. The high platelet count was observed in patients with sickle-cell anemia and Hb-S-β-thalassemia without palpable spleen. The independence of the splenic functions of these patient were emphasized.
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