EVALUATION OF GROWTH HORMONE (GH) SECRETION COMPARING THE RESPONSE TO 1-44 GROWTH HORMONE RELEASING FACTOR (1-44 GRF) WITH THE SLEEP SECRETION AND THE RESPONSES TO PHARMACOLOGIC STIMULI

摘要

GH secretion was evaluated in 54 short patients with mean growth retardation of 3.3 ± 0.96 SD ( 32 M and 22 F aged 5 to 19 years), comparing their peak response to GRF 1-44 Sanofi 2 μg/kg IV (GRF P) and to 2 conventional pharmacologic stimuli (arginine, insulin, glucagon, ornithine) (PS P) with the peak value of their sleep secretion (SS P). GRF P was more significantly correlated with PS P(r = 0.53, p 10 ng/ml; group II = 5 completely GH deficient with both PS and SS peaks