Dehydration when of sufficient severity depresses the glomerular filtration rate significantly. The high inulin and creatinine U/P ratios during dehydration indicate water conservation by the tubules. Depressed glomerular filtration rates may enhance this mechanism.The tendency to the lower than expected rise in U/P ratio with low urine flows during dehydration in diarrheal disease suggests disturbed tubular mechanism for water reabsorption.Glomerular filtration rate is rapidly restored with the intravenous administration of fluid. Restoration to normal values may proceed at a slower pace in the sick infant.
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