The Toxicity of 125IUdR in Cultured Mouse BP8 Tumour Cells

摘要

The toxicity of the low-energy electrons from 125I in labelled IUdR was assayed by labelling the DNA of BP8 mouse tumour cells with the nucleoside and studying their subsequent growth in culture. Toxicity was observed in cells grown in medium containing more than 0·01 μCi/ml. The amount of label incorporated into cells showing deleterious effects is compared with that reported by others.