Correlation between Oxidative Stress Markers and Atherogenic Indices in Type 2 Diabetes Mellitus

摘要

Worldwide, approximately 200 million individuals are currently suffering from Type 2 diabetes mellitus (DM). Diabetes mellitus is associated with hyperglycemia; which induces oxidative stress that is responsible for the various complications associated with the disease. This study was designed to know the relationship between oxidative stress and atherogenic indices of plasma in Type 2 diabetic and non-diabetic subjects. A total number of eighty (80) subjects comprising of 58 diabetic subjects with mean age (62.91±10.57) years and 22 non-diabetic subjects with mean age (55.27±16.62) years were studied. Estimation of enzymatic and non-enzymatic oxidative stress markers (which included MDA, SOD, GPx, CAT, Uric acid and Albumin) and atherogenic indices (TCHOL, TG, HDL, LDL) were done respectively using standard spectrophotometric techniques. The mean plasma of SOD, GPx, CAT and albumin were significantly lower in diabetic subjects compared with control group. However, TChol, HDL, MDA and uric acid were significantly higher in diabetic subjects compared with controls. The findings of this study showed significant differences in dyslipidemia, lipid peroxidation and increase of oxidative stress markers from na?ve type 2 diabetic subjects through controls. Thus, early diagnosis and management of this condition is necessary in order to incorporate antioxidant supplement as a supportive therapy for adequate glycaemic control.