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Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain

机译:加热的利多卡因/丁卡因贴剂治疗of肌腱痛

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Introduction: The pain of patellar tendinopathy (PT) may be mediated by neuronal glutamate and sodium channels. Lidocaine and tetracaine block both of these channels. This study tested the self-heated lidocaine-tetracaine patch (HLT patch) in patients with PT confirmed by physical examination to determine if the HLT patch might relieve pain and improve function. Methods: Thirteen patients with PT pain of ≥14 days' duration and baseline average pain scores ≥4 (on a 0–10 scale) enrolled in and completed this prospective, single-center pilot study. Patients applied one HLT patch to the affected knee twice daily for 2–4 hours for a total of 14 days. Change in average pain intensity and interference (Victorian Institute of Sport Assessment [VISA]) scores from baseline to day 14 were assessed. No statistical inference testing was performed. Results: Average pain scores declined from 5.5 ± 1.3 (mean ± standard deviation) at baseline to 3.8 ± 2.5 on day 14. Similarly, VISA scores improved from 45.2 ± 14.4 at baseline to 54.3 ± 24.5 on day 14. A clinically important reduction in pain score (≥30%) was demonstrated by 54% of patients. Conclusion: The results of this pilot study suggest that topical treatment that targets neuronal sodium and glutamate channels may be useful in the treatment of PT.
机译:简介:pa肌腱病(PT)的疼痛可能由神经元谷氨酸和钠通道介导。利多卡因和丁卡因阻断了这两个通道。这项研究测试了经身体检查证实的PT患者的自发热利多卡因-丁卡因贴片(HLT贴片),以确定HLT贴片是否可以缓解疼痛并改善功能。方法:13名持续时间≥14天且基线平均疼痛评分≥4(0-10分)的PT疼痛患者参加并完成了这项前瞻性,单中心的前瞻性研究。患者每天两次在患处膝盖上应用HLT贴片两次,持续2-4小时,共14天。评估了从基线到第14天的平均疼痛强度和干扰(维多利亚运动评估[VISA])得分的变化。没有执行统计推断测试。结果:平均疼痛评分从基线时的5.5±1.3(平均值±标准偏差)下降到第14天的3.8±2.5。同样,VISA得分从基线时的45.2±14.4改善到第14天的54.3±24.5。 54%的患者表现出疼痛评分(≥30%)。结论:该初步研究的结果表明,针对神经元钠和谷氨酸通道的局部治疗可能对PT有用。

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