首页> 外文期刊>Journal of Korean medical science. >Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery
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Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery

机译:胃癌患者的血清胰岛素样生长因子(IGFs)和IGF结合蛋白(IGFBP)-3:手术诱导的IGFBP-3蛋白酶活性

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摘要

Recent findings have indicated that insulin-like growth factors (IGF-I and IGF-II) may play a role in neoplasia. Alteration of serum IGFs or IGF Binding Proteins (IGFBPs) have been reported in some tumors. In this study, we measured serum IGF-I, IGF-II and IGFBPs profile in gastric cancer by radioimmunoassay and Western ligand blots. The serum IGF-I level in gastric cancer was significantly lower than in control subjects (65.2 ± 26.5 vs 148.4 ± 55.2 ng/ml, p
机译:最近的发现表明,胰岛素样生长因子(IGF-I和IGF-II)可能在肿瘤形成中起作用。在一些肿瘤中已经报道了血清IGF或IGF结合蛋白(IGFBP)的改变。在这项研究中,我们通过放射免疫分析和Western配体印迹测量了胃癌中血清IGF-I,IGF-II和IGFBPs的分布。胃癌的血清IGF-I水平显着低于对照组(65.2±26.5 vs 148.4±55.2 ng / ml,p

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