Effects of pidotimod combined with dermatophagoides farinae drops on the immune inflammatory response of children with allergic rhinitis complicated by asthma

摘要

Objective: To investigate the effects of pidotimod combined with dermatophagoides farinae drops on the immune inflammatory response of children with allergic rhinitis complicated by asthma. Methods: A total of 142 children with allergic rhinitis complicated by asthma who were treated in this hospital between March 2014 and January 2017 were selected and divided into the control group (n=71) and study group (n=71) by random number table method. Control group were treated with dermatophagoides farinae drops, and study group received pidotimod combined with dermatophagoides farinae drops therapy. The differences in serum contents of immunoglobulin and inflammatory cytokines were compared between two groups of children before treatment and after 1 month of treatment. Results: There was no statistically significant difference in serum contents of immunoglobulin, Th1/Th2 cytokines and Th17/Treg cytokines between the two groups before treatment. After 1 month of treatment, serum sIgE content was lower than that of control group whereas sIgG4 content was higher than that of control group; serum Th1 cytokines IFN-γ and IL-2 contents were higher than those of control group whereas Th2 cytokines IL-4 and IL-5 contents were lower than those of control group; serum Th17 cytokine IL-17 content was lower than that of control group whereas Treg cytokine IL- 10 content was higher than that of control group. Conclusion: Pidotimod combined with dermatophagoides farinae drops can effectively optimize the immune function and suppress the systemic inflammatory response in children with allergic rhinitis complicated by asthma.