FABRICATION OF BIOCOMPATIBLE NANO-CARBONATEDHYDROXYAPATITE/POLYMER SPONGY SCAFFOLDS

摘要

Spongy scaffolds containing nano-carbonated hydroxyapatite (nCHA), with compositionsCa10(PO4)6-y(CO3)y(OH)2, with y=0,2,4, were prepared by the lyophilization method usingdifferent polymers such as natural gelatin (GE), chitosan (CS) and polyvinyl alcohol(PVA), alone or in their combinations. The samples were characterized by using XRD,SEM, and FTIR techniques. All the scaffolds were found to have porosities above 70%and their morphology changed significantly for one nCHA/polymer combination to theother. The nCHA containing scaffolds mediated cytotoxicity (MTT assay) and cellattachment studies were carried out on rat bone marrow derived mesenchymal stem cells(rMSC). Evident cell attachment and no significant cytotoxicity was observed. Thepreparation of spongy scaffolds and their biocompatibility augment their potential use intissue engineering and biomedical applications.