Quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging of hepatic benign and malignant lesions and their clinical value

摘要

Objective: To determine the quantitative parameter levels of dynamic contrast-enhancedmagnetic resonance imaging (MRI) of hepatic benign and malignant lesions and to exploretheir value for the evaluation of the disease. Methods: A total of 67 patients with primaryliver cancer and 78 patients with hepatic benign lesion were selected as the liver cancer groupand hepatic benign lesion group respectively. The preoperative quantitative parameter levelsof dynamic contrast-enhanced MRI of the two groups were measured, and the correlationof the specific parameter levels with liver cancer-related proliferation and invasion geneexpression was evaluated. Results: The mean time to enhance (MET) and maximum slopeof increase (MSI) levels of the liver cancer group were lower than those of the hepatic benignlesion group while the maximum slope of decrease (MSD) level was higher than that of thehepatic benign lesion group. Proliferation genes PRMT5, CDCA5, SIRT2, XIAP and Cep55mRNA expression in the lesion tissues of the liver cancer group were all higher than thoseof the hepatic benign lesion group; invasion genes Cripto-1 and IFITM3 mRNA expressionwere higher than those of the hepatic benign lesion group while KLF4 and HOXA9 mRNAexpression were lower than those of the hepatic benign lesion group. Pearson test showed thatthe quantitative parameters MET, MSI and MSD levels of dynamic contrast-enhanced MRIin liver cancer tissues were directly correlated with the proliferation and invasion activity ofcancer cells. Conclusion: The quantitative parameters MET, MSI and MSD levels of dynamiccontrast-enhanced MRI of liver cancer are significantly abnormal, and the specific levels couldobjectively reflect the tumor malignancy.