Effect of dezocine pretreatment on emergence agitation and related internal environment changes in children with general anesthesia surgery

摘要

Objective: To study the effect of dezocine pretreatment on the emergence agitation and related internal environment changes in children with general anesthesia surgery. Methods: A total of 200 children who underwent general anesthesia surgery in the Central Hospital of Xiaogan between January 2015 and December 2017 were enrolled in the study and divided into two groups by random number table method, dezocine group received routine general anesthesia and intravenous injection of dezocine 30 min before the end of surgery, and control group received routine general anesthesia and intravenous injection of saline 30 min before the end of surgery. The CHEPOS score of emergence agitation was performed during anesthesia recovery; the levels of inflammatory stress mediators in serum as well as the expression of stress signal molecules and inflammatory signal molecules in peripheral blood were measured before anesthesia induction and during anesthesia recovery. Results: The CHEPOS score of emergence agitation of dezocine group was lower than that of control group; compared with those of same group before anesthesia induction, serum ACTH, Cor, INS, ICAM1 and TNF-α levels as well as peripheral blood CHOP, GRP78, JNK, c-jun, CD14 and SR expression intensity of both groups of patients were significantly higher whereas IRS-1, IRS-2 and PKB expression intensity were significantly lower during anesthesia recovery, and serum ACTH, Cor, INS, ICAM1 and TNF-α levels as well as peripheral blood CHOP, GRP78, JNK, c-jun, CD14 and SR expression intensity of dezocine group during anesthesia recovery were significantly lower than those of control group whereas IRS-1, IRS-2 and PKB expression intensity were significantly higher than those of control group. Conclusions: Dezocine pretreatment has improving effect on the emergence agitation and related internal environment changes in children with general anesthesia surgery.