Correlation of PECAM-1 gene C373G locus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia

摘要

Objective: To study the correlation of PECAM-1 gene C373G locus polymorphism withendothelial injury and placental pathological damage in patients with preeclampsia. Methods:Pregnant women with preeclampsia and healthy pregnant women delivering in ObstetricsDepartment of Yibin Second People’s Hospital between May 2014 and September 2016were selected and enrolled in PE group and control group respectively. Peripheral bloodwas collected to determine PECAM-1 gene C373G polymorphism as well as the contents ofendothelial injury molecules sEng, PAR-1, sFlt-1 and ET-1; placenta tissue was collected todetermine the contents of pathological damage molecules Gadd45α, TIMP2, Fas, Apaf-1 andcaspase-3. Results: PECAM-1 gene C373G locus GC and GG genotype constituent ratioand allele G constituent ratio in peripheral blood of PE group were significantly higher thanthose of control group while CC genotype constituent ratio and allele C constituent ratio weresignificantly lower than those of control group. sFlt-1, sEng, PAR-1 and ET-1 contents inserum as well as Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3 contents in placenta of PE groupwere significantly higher than those of control group; sFlt-1, sEng, PAR-1 and ET-1 contentsin serum as well as Gadd45α, TIMP2, Fas, Apaf-1 and caspase-3 contents in placenta of PEpatients with PECAM-1 gene C373G locus GC and GG genotypes were higher than those ofPE patients with CC genotype. Conclusion: Increased allele G in PECAM-1 gene C373G lociis closely correlated with endothelial injury and placental pathological damage in patients withpreeclampsia.