CD80 and CD86 expression in nasopharyngeal carcinoma and their correlation with recurrence after endoscopic sinus surgery as well as tumor invasion and apoptosis

摘要

Objective: To study CD80 and CD86 expression in nasopharyngeal carcinoma and theircorrelation with recurrence after endoscopic sinus surgery as well as tumor invasion andapoptosis. Methods: Patients with nasopharyngeal carcinoma who received surgical resectionin Nanchong Central Hospital between February 2013 and March 2014 were collected anddivided into recurrence group and non-recurrence group according to the recurrence 3 yearsafter surgery. Normal nasal mucosa tissue for biopsy during the same period was collected,and the expression levels of CD80, CD86 as well as apoptosis molecules and invasionmolecules in lesions were detected. Results: CD80, ARD1, Survivin, Shh, Ptch1, S100A4,Ezrin and N-cadherin expression in lesions of recurrence group and non-recurrence groupwere significantly higher than those of control group, and CD80, ARD1, Survivin, Shh, Ptch1,S100A4, Ezrin and N-cadherin expression in lesions of recurrence group were significantlyhigher than those of non-recurrence group; CD86 expression in lesions were not significantlydifferent among recurrence group, non-recurrence group and control group. ARD1, Survivin,Shh, Ptch1, S100A4, Ezrin and N-cadherin mRNA expression in nasopharyngeal carcinomalesions with high CD80 expression were significantly higher than those in nasopharyngealcarcinoma lesions with low CD80 expression. Conclusion: The high expression of CD80 innasopharyngeal carcinoma can participate in tumor recurrence through promoting the cellproliferation and invasion.