首页> 外文期刊>Japanese Journal of Pharmacology >The Effects of Centrally Acting Muscle Relaxants on the Intrathecal Noradrenaline-Induced Facilitation of the Flexor Reflex Mediated by Group II Afferent Fibers in Rats
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The Effects of Centrally Acting Muscle Relaxants on the Intrathecal Noradrenaline-Induced Facilitation of the Flexor Reflex Mediated by Group II Afferent Fibers in Rats

机译:中枢作用肌肉松弛剂对鞘内去甲肾上腺素诱导的Ⅱ类传入纤维介导的屈肌反射的促进作用

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References(32) Cited-By(9) The effects of centrally acting muscle relaxants on the flexor reflex mediated by group II afferent fibers (group II flexor reflex) in anesthetized intact rats and on the intrathecal noradrenaline-HCl-induced facilitation of the group II flexor reflex in anesthetized spinal rats were investigated. In anesthetized intact rats, mephenesin, tolperisone-HCl, chlorpromazine-HCl and baclofen inhibited the group II flexor reflex dose-dependently, whereas the inhibitory effect of tizanidine-HC1 was bell-shaped. The effect of diazepam tended to be saturated. In anesthetized spinal rats, mephenesin, tolperisone-HCl, chlorpromazine-HCl, diazepam and baclofen also depressed the group II flexor reflex, but tizanidine-HCl slightly increased it. The intrathecal noradrenaline-HCl-induced facilitation of the group II flexor reflex was not affected by mephenesin or diazepam, but was inhibited by tizanidine-HCl, tolperisone-HCl, chlorpromazine-HCl and baclofen. These results suggest that compounds with centrally acting muscle relaxant activity depress the group II flexor reflex in different manners, and the inhibition of descending noradrenergic tonic facilitation within the spinal cord participates in the depressant action of the group II flexor reflex produced by tolperisone-HCl, tizanidine-HCl, chlorpromazine-HCl and baclofen.
机译:参考文献(32)(9)被中枢作用的肌肉松弛剂对麻醉的完整大鼠中II组传入纤维介导的屈肌反射(II组屈肌反射)的影响以及鞘内去甲肾上腺素-HCl诱导的该组的促进作用研究了麻醉脊髓大鼠的II屈肌反射。在麻醉的完整大鼠中,美芬素,盐酸托哌酮,盐酸氯丙嗪和巴氯芬剂量依赖性地抑制II组屈肌反射,而替扎尼定HCl的抑制作用呈钟形。地西epa的作用趋于饱和。在麻醉的脊髓大鼠中,甲吗啡肽,盐酸托哌酮,盐酸氯丙嗪,地西epa和巴氯芬也抑制了II组屈肌反射,而替扎尼定-HCl则使其略有增加。鞘内去甲肾上腺素-HCl诱导的II组屈肌反射的促进作用不受美芬素或地西epa的影响,但被替扎尼定-HCl,托哌酮-HCl,氯丙嗪-HCl和巴氯芬抑制。这些结果表明,具有中枢作用的肌肉松弛活性的化合物以不同的方式抑制II组屈肌反射,而抑制脊髓内降甲肾上腺素的强直性促进作用参与了托哌酮-HCl产生的II组屈肌反射的抑制作用,替扎尼定盐酸盐,氯丙嗪盐酸盐和巴氯芬。

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