STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM)

摘要

References(13) Cited-By(1) NEM administered i.p. produced apparent accumulation- of exudative ascites, followed by an increase in hematocrit values and neutrophilia in differential leukocytes counts. Dilatation of vascular capillaries together with hyperemia, scattered foci of perivascular infiltration of monocytes and precipitation of fibrin in mesentery were histologically observed after administration of NEM. These phenomena were not observed in the liver. NEM, when intracutaneously administered, resulted in obvious edema in rat hind paw with a marked increase in capillary permeability. The inflammatory action of NEM was completely blocked by cysteine, but not by cortisone or indomethadine, suggesting that NEM induced edema results from the reaction with selective SH groups in tissues.