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ATP4 and ciliation in the neuroectoderm and endoderm of Xenopus embryos and tadpoles

机译:爪蟾胚胎和t神经外胚层和内胚层中的ATP4和纤化作用

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During gastrulation and neurulation, foxj1 expression requires ATP4a-dependent Wnt/β-catenin signaling for ciliation of the gastrocoel roof plate (Walentek et al. Cell Rep . 1 (2012) 516–527.) and the mucociliary epidermis (Walentek et al. Dev. Biol. (2015)) of Xenopus laevis embryos. These data suggested that ATP4a and Wnt/β-catenin signaling regulate foxj1 throughout Xenopus development. Here we analyzed whether foxj1 expression was also ATP4a-dependent in other ciliated tissues of the developing Xenopus embryo and tadpole. We found that in the floor plate of the neural tube ATP4a-dependent canonical Wnt signaling was required for foxj1 expression, downstream of or in parallel to Hedgehog signaling. In the developing tadpole brain, ATP4-function was a prerequisite for the establishment of cerebrospinal fluid flow. Furthermore, we describe foxj1 expression and the presence of multiciliated cells in the developing tadpole gastrointestinal tract. Our work argues for a general requirement of ATP4-dependent Wnt/β-catenin signaling for foxj1 expression and motile ciliogenesis throughout Xenopus development.
机译:在胃排空和神经形成过程中,foxj1表达需要依赖ATP4a的Wnt /β-catenin信号传导来纤化胃小肠顶板(Walentek等人,Cell Rep。1(2012)516–527。)和粘膜纤毛表皮(Walentek等人。非洲爪蟾胚胎的开发(2015))。这些数据表明,ATP4a和Wnt /β-catenin信号在整个非洲爪蟾的发育过程中均调节foxj1。在这里,我们分析了在非洲爪蟾胚胎和t的其他纤毛组织中foxj1表达是否也依赖ATP4a。我们发现在神经管的底板中,Hoxhog信号的下游或与之平行地,foxj1表达需要ATP4a依赖的经典Wnt信号。在发育中的t脑中,ATP4功能是建立脑脊液流动的先决条件。此外,我们描述了foxj1表达和the发育中的胃肠道中多纤毛细胞的存在。我们的工作主张在非洲爪蟾的整个发育过程中,foxj1表达和运动性纤毛发生均需要依赖ATP4的Wnt /β-catenin信号传导。

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