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Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung

机译:肺癌类癌切除病例的临床病理特征及预后

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BackgroundLung carcinoid tumors are rare, low-grade, malignant neoplasms with some unclear features. The aim of this study was to analyze clinicopathological features and long-term survival in patients with primary lung carcinoid tumors. MethodsPatients who underwent surgery in our clinic and were diagnosed with carcinoid tumors, between August 1997 and July 2012, were included in the study. Patient characteristics and clinicopathological factors were retrospectively evaluated. ResultsBronchial carcinoids comprised only 1.0% of lung cancer cases treated by resection. They are classified into two distinct categories: typical carcinoid (TC) and atypical carcinoid (AC) tumors. AC tumors occurred more frequently in younger patients and in smokers, and had a poorer prognosis than TC tumors. Overall three and five-year survival rates for TC and AC were 92.6% and 81.1%, respectively. Univariate analysis showed that tumor size ( P =?0.012) and histological type ( P =?0.013) are prognostic factors. Multivariate analysis revealed that only tumor size ( P =?0.044) was an independent prognostic factor. ConclusionsThe prognosis for bronchial carcinoid tumors was better than other types of lung cancer and TC was significantly better than AC. Radical lymph node dissection was the best treatment, with complete removal of the tumor. Tumor size was an independent prognostic factor for bronchial carcinoid tumors.
机译:背景肺类癌是罕见的低度恶性肿瘤,特征尚不清楚。这项研究的目的是分析原发性肺类癌患者的临床病理特征和长期生存。方法将1997年8月至2012年7月在我们诊所接受手术治疗并被诊断患有类癌的患者纳入研究。回顾性评估患者特征和临床病理因素。结果支气管类癌仅占手术切除肺癌病例的1.0%。它们分为两个不同的类别:典型类癌(TC)和非典型类癌(AC)肿瘤。 AC肿瘤在年轻患者和吸烟者中更常见,且预后较TC肿瘤差。 TC和AC的总体三年和五年生存率分别为92.6%和81.1%。单因素分析显示,肿瘤大小(P =?0.012)和组织学类型(P =?0.013)是预后因素。多因素分析显示,只有肿瘤大小(P =?0.044)是独立的预后因素。结论支气管类癌的预后优于其他类型的肺癌,TC明显优于AC。根治性淋巴结清扫术是最好的治疗方法,可以完全切除肿瘤。肿瘤大小是支气管类癌的独立预后因素。

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