A Comparison between High Frequency Positive Pressure Ventilation and Intermittent Positive Pressure Ventilation during Closed Mitral Valvotomy

摘要

Background: Patients with tight mitral stenosis usually suffer low cardiac output symptoms and elevated pulmonary vascular resistance. They may be candidates for the use of high frequency positive pressure ventilation (HFPPV). We aimed to compare HFPPV with intermittent positive pressure ventilation (IPPV) in patients subjected to closed mitral valvotomy (CMV).Methods: Twenty-four patients subjected to closed mitral valvotomy were randomly allocated to ventilation with IPPV or HFPPV. The minute volume in the IPPV group was given as a tidal volume of 10 ml/kg and a respiratory rate of 14 breaths/min, while in the HFPPV it was given as a tidal volume of 3 ml/kg and a respiratory rate of 60 breaths/min. Heart rate, arterial blood pressure, right atrial pressure (RAP), O2 saturation (SpO2), end-tidal CO2 (PeCO2), arterial CO2 tension (PaCO2) and arterial O2 tension (PaO2) were recorded during the procedure. In addition, interferences to correct hypoxaemia were recorded. Dead space fraction was calculated.Results: RAP decreased significantly during surgery in HFPPV group when compared to IPPV group. Interferences with manual ventilation to correct hypoxaemia were less frequent in HFPPV group compared to IPPV group. In each group dead space fraction increased significantly during surgery when compared to the baseline values. Surgeon's complaint was more frequent in IPPV group.Conclusion: The use of HFPPV during closed mitral valvotomy provides a safe alternative to the conventional IPPV with possible better right side unloading, less hypoxic episodes and better surgical conditions. Introduction Tight mitral stenosis is one of the most prevalent valve disorders in Egypt. Closed mitral valvotomy (CMV) is the technique of choice for treatment of rheumatic mitral stenosis (1,2). Percutaneous mitral balloon valvoplasty (PMBV) may be the preferred approach when surgical intervention is contraindicated.Low cardiac output and high pulmonary vascular resistance (PVR) are the consequences of mitral valve stenosis (3). Therefore, patients with mitral stenosis usually suffer limited exercise tolerance (4). During CMV, the critical period of dilatation of the valve with the surgeon's right index finger and Tubbs dilator is usually associated with profound decrease in the cardiac output (CO) and sometimes hypoxaemia. The mode of ventilation during this period may have additional effects. High frequency positive pressure ventilation (HFPPV) was reported to have more favourable effects on cardiac output, pulmonary vascular resistance and oxygen transport compared to conventional intermittent positive pressure ventilation (5). The use of HFPPV may be advantageous during the period of valvotomy in respects of haemodynamics, oxygenation and easiness of surgical access. To test this hypothesis, patients subjected to CMV were randomly allocated to ventilation with either IPPV or HFPPV. Haemodynamics, oxygenation, ventilation and easiness of surgical access were considered the outcome measures. Patients and methods This randomised comparative study was approved by the Hospital Ethics Committee and informed written consents were obtained from all patients. Twenty-four patients suffering from tight mitral stenosis and subjected to CMV were enrolled. Patients with mitral regurgitation, atrial thrombi or rapid atrial fibrillation were excluded from the study. Redo cases were also excluded from the study. Preoperative evaluation included history, clinical examination, ECG, chest X-ray, laboratory tests and echocardiography. Patients received oral diazepam 5 mg the night and morning of the operation. At the operative suite, patients received midazolam 2–4 mg and fentanyl 50–70 μg intravenously. Monitoring included ECG, pulse oximetry and side-stream capnography. An arterial cannula was inserted in the brachial artery of the non-dominant limb for blood pressure monitoring and blood gas analysis. The right internal jugular vein was cannulated for right atrial pr