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Rapamycin selectively alters serum chemistry in diabetic mice

机译:雷帕霉素选择性改变糖尿病小鼠的血清化学

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The study was undertaken to explore the effect of rapamycin, an anti-inflammatory agent, on the metabolic profile of type 2 diabetic mice. Seven-month-old diabetic db/db mice and their lean littermate non-diabetic controls (db/m) were randomized to receive control chow or chow mixed with rapamycin (2.24 mg/kg/day) (each group n =20, males and females) for 4 months and sacrificed. Serum samples were analyzed for the measurement of glucose, creatinine, blood urea nitrogen (BUN), alkaline phosphatase (ALP), alanine aminotransferase (ALT), total cholesterol, total triglyceride, and total protein, using the automated dry chemistry analysis. Rapamycin elevated serum glucose in female diabetic mice. Serum creatinine tended to be higher in diabetic mice but was not affected by rapamycin; there was no difference in BUN levels among the groups. Serum ALP was elevated in diabetic mice and rapamycin lowered it only in female diabetic mice; serum ALT levels were increased in female diabetic mice, unaffected by rapamyc...
机译:该研究旨在探讨雷帕霉素(一种抗炎药)对2型糖尿病小鼠代谢谱的影响。将7个月大的db / db糖尿病小鼠和同窝的非糖尿病瘦小鼠(db / m)随机接受对照食物或雷帕霉素(2.24 mg / kg /天)混合的食物(每组n = 20,雄性和雌性)持续4个月并处死。使用自动干化学分析分析血清样品,以测量葡萄糖,肌酐,血尿素氮(BUN),碱性磷酸酶(ALP),丙氨酸氨基转移酶(ALT),总胆固醇,总甘油三酸酯和总蛋白质。雷帕霉素在雌性糖尿病小鼠中升高血清葡萄糖。糖尿病小鼠的血清肌酐趋于升高,但不受雷帕霉素影响。各组之间的BUN水平无差异。糖尿病小鼠血清ALP升高,雷帕霉素仅在雌性糖尿病小鼠中降低。雌性糖尿病小鼠的血清ALT水平升高,不受雷帕霉素的影响。

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