For people at ages 5 to 45 years, trauma is second only to HIV/AIDS as a cause of death. Each year, worldwide, over three million people die as a result of trauma, many after reaching hospital.1 Among trauma patients who do survive to reach hospital, exsanguination is a common cause of death, accounting for nearly half of in-hospital trauma deaths.2 Central nervous system injury and multi-organ failure account for most of the remainder, both of which can be exacerbated by severe bleeding.
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