Esquizofrenia resistente al tratamiento: ?hemos tomado una decisión?

摘要

Introduction: For decades, the term refractory psychosis has been widely used, but not clearly defined. Although the exact mechanisms by which treatment-resistance is developed are unknown,some factors will lead to bigger vulnerability to present it. It remains unclear if it is just a severeextreme at the end of the psychosis spectrum, or a subtype of schizophrenia. Objective: Todetermine if there is current consensus in the concept of refractory psychosis. Methods: Review ofdifferent guidelines about it (EMEA, SIGN, NICE, BPA, APA, CPA and WFSBP) and comparisonof their definitions and approach designs. Results: Consulted guidelines show differences in the waythey define refractory psychosis, but uniformity in their management proposal. Conclusion: Thereis no consensus in the operational definition of treatment resistant psychosis.