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Estimation and Assessment of D-Dimer Levels in Sudanese Patients with Pulmonary Tuberculosis

机译:苏丹肺结核患者D-二聚体水平的估计和评估

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Background: The association between pulmonary tuberculosis and a hypercoagulable state is well documented. An increased D-dimer level is linked with increasing the mortality of pulmonary tuberculosis infection. Objective: The current study aimed to the estimation and assessment of the D-dimer levels in Sudanese patients with pulmonary tuberculosis. Material and Methods: This is a case control study that was conducted during March 2016 at Faculty of Medical Laboratory Sciences, Alneelain University, Khartoum, Sudan. A total of 70 subjects were included in this study, classified into two groups. The first group consists of ?40 subjects, among which 30 (75%) were males and 10 (25%) were female; their mean age is 32.3 years classified as patients group; of other 30 normal healthy subjects, 15 (50%) were female and 15 (50%) were males; their mean age was 33.1 years in the second group as normal control group. The platelet poor plasma was prepared immediately from citrated blood by centrifuging at 2000 rpm for 15 minutes. The data were collected by structured interview and questionnaire, and then analyzed by using a computer program statistical package for social sciences (SPSS) version 21. The D-dimer levels were measured using immunometric assay (Nyco Card READER II). Result: The present study found that the D-dimer levels were statistically significantly higher in pulmonary tuberculosis patients compared to the normal healthy control groups (Mean ± SD 0.82 ± 0.54 vs. 0.33 ± 0.13 with p value 0.00). Conclusion: This study showed that Sudanese patient with pulmonary tuberculosis has increased the plasma D-dimer level, and this abnormality could be prone to Deep Vein Thrombosis (DVT).
机译:背景:肺结核与高凝状态之间的关联已有充分文献记载。 D-二聚体水平升高与肺结核感染的死亡率增加有关。目的:本研究旨在评估和评估苏丹肺结核患者的D-二聚体水平。材料和方法:这是一项病例对照研究,于2016年3月在苏丹喀土穆的Alneelain大学医学实验室科学学院进行。本研究共包括70名受试者,分为两组。第一组由40位受试者组成,其中30位(75%)是男性,而10位(25%)是女性。他们的平均年龄为32.3岁,被归为患者组;在其他30名正常健康受试者中,女性15名(50%),男性15名(50%);第二组为正常对照组,平均年龄为33.1岁。通过以2000 rpm离心15分钟,立即从柠檬酸血液中制备贫血小板血浆。通过结构化访谈和问卷调查收集数据,然后使用计算机科学社会科学统计软件包(SPSS)21版进行分析。D-二聚体水平使用免疫测定法(Nyco Card READER II)进行测量。结果:本研究发现,与正常健康对照组相比,肺结核患者的D-二聚体水平在统计学上显着更高(平均值±SD 0.82±0.54与0.33±0.13,p值0.00)。结论:这项研究表明苏丹肺结核患者血浆D-二聚体水平升高,这种异常可能易于引起深静脉血栓形成(DVT)。

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